US 10,245,276 B2Granted

Co-crystals of tramadol and coxibs

AssigneeLaboratorios Del Dr. Esteve, S.A.

InventorsCarlos Ramon Plata Salaman, Nicolas Tesson

Life of this patent

Estimating the term…

Abstract

The present invention relates to co-crystals of tramadol and co-crystal formers selected from NSAIDs/coxibs, processes for preparation of the same and their uses as medicaments or in pharmaceutical formulations, more particularly for the treatment of pain.

Claims4

Dependent claims

A co-crystal comprising (rac)-tramadol.HCl and celecoxib in a molecular ratio of 1:1, characterized in that it has an orthorhombic unit cell with the following dimensions:

a=11.0323(7) Å
b=18.1095(12) Å
c=17.3206(12) Å.

Dependencies are inferred from the claim text.

Facts

Application: 15/231,915Filed 9 Aug 2016 · continuation
Priority: WO PCT/EP2009/00745116 Oct 2009
Published: US 2017/0027965 A12 Feb 2017
Granted: 2 Apr 2019
Term ends: Not estimatedThe source records don’t support an estimate.

Classification24 codes

A61K 31/635
Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide: having a heterocyclic ring, e.g.…
A61K 9/16
Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles: agglomerates;…
A61K 31/135
Amines: having aromatic rings , e.g. ketamine, nortriptyline
A61K 31/137
Having aromatic rings , e.g. ketamine, nortriptyline: arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone

Family

PCT/EP2010/002385Parent of this continuation · filed 19 Apr 2010
Application14/066,127Parent of this continuation · filed 29 Oct 2013
US 8,598,152 B2Parent of this continuation · filed 3 Dec 2013
Application14/665,055Parent of this continuation · filed 23 Mar 2015
US 9,012,440 B2Parent of this continuation · filed 21 Apr 2015
US 2017/0027965 A1Pre-grant publication · published 2 Feb 2017
Application13/395,021Parent of this continuation
US 2012/0172398 A1Published application
US 2014/0057879 A1Published application
US 2015/0196503 A1Published application
US 10,245,276 B2This patent

From the US filing history. Foreign family members aren’t listed.

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