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US 10,245,274 B2Granted
Chitosan-based matrices and uses thereof
AssigneeThe Trustees of the University of Pennsylvania
InventorsBert W. O'Malley, Daqing Li, David Paulson
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AssigneeThe Trustees of the University of Pennsylvania
InventorsBert W. O'Malley, Daqing Li, David Paulson
Estimating the term…
This invention relates a controlled release delivery composition for an otorhinolaryngology and otorhinolaryngology-associated pathology, conditions, indications or their combination, Head and Neck associated pathology conditions, indications or their combination, or their combination, using a chitosan-glycerophosphate (CGP) hydrogel and an agent or a bio-materials. Additionally, provided methods of treating an otorhinolaryngology and otorhinolaryngology-associated pathology, conditions, indications or their combination, Head and Neck associated pathology conditions, indications or their combination, or their combination.
A method of treating an otorhinolaryngology-associated pathology, or Head and Neck associated pathology in a subject, comprising administering through the auditory bulla a composition onto the round window membrane of the subject for release of an agent to the perilymph of the inner ear of the subject, wherein said composition comprises a solution of chitosan-glycerophosphate (CGP) and the agent, wherein the agent dissolved therein is present in an amount effective in the treatment of the otorhinolaryngology-associated pathology, or Head and Neck associated pathology, wherein auditory functions are preserved by said administering.
Dependencies are inferred from the claim text.