US 10,245,267 B2 · Biaryl amide compounds as kinase inhibitors

Biaryl amide compounds as kinase inhibitors

AssigneeNovartis AG

InventorsRobert John Aversa, Paul Andrew Barsanti, Matthew T. Burger, Michael Patrick Dillon, Alan Dipesa, Cheng Hu, Yan Lou, Gisele A. Nishiguchi, Yue Pan, Valery Rostislavovich Polyakov, Savithri Ramurthy, Alice C. Rico, Lina Quattrocchio Setti, Aaron Smith, Sharadha Subramanian, Benjamin R. Taft, Huw Roland Tanner, Lifeng Wan, Naeem Yusuff

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Abstract

The present invention provides compounds of Formula (I) as described herein, and salts thereof, and therapeutic uses of these compounds for treatment of disorders associated with Raf kinase activity. The invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds and a therapeutic co-agent.

Claims4

Dependent claims

A compound, or a pharmaceutically acceptable salt thereof, selected from:

Dependencies are inferred from the claim text.

Facts

Application

15/601,423Filed 22 May 2017 · division

Priority

14 Mar 2013

Published

US 2017/0260207 A114 Sep 2017

Granted

2 Apr 2019

Term ends

Not estimatedThe source records don’t support an estimate.

Classification53 codes

A61K 31/5377
1,4-Oxazines, e.g. morpholine: not condensed and containing further heterocyclic rings, e.g. timolol
A61K 31/444
Containing further heterocyclic ring systems: containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
A61K 31/501
Pyridazines; Hydrogenated pyridazines: not condensed and containing further heterocyclic rings
A61K 31/5375
Having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines: 1,4-Oxazines, e.g. morpholine

Family

Application61/783,558Us provisional application · filed 14 Mar 2013

PCT/US2014/026107Parent of this division · filed 13 Mar 2014

US 2017/0260207 A1Pre-grant publication · published 14 Sep 2017

Application14/774,431Parent of this division

US 9,694,016 B2Parent of this division

US 2016/0038504 A1Published application

US 10,245,267 B2This patent

From the US filing history. Foreign family members aren’t listed.