Substituted indol-5-ol derivatives and their therapeutic applications
AssigneeNantBio, Inc.
InventorsChunlin Tao, Qinwei Wang, David Ho, Tulay Polat, Laxman Nallan, Patrick Soon-Shiong
Life of this patent
Estimating the term…
Abstract
The present invention relates generally to the use of compounds to treat a variety of disorders, diseases and pathologic conditions and more specifically to the use of substituted indol-5-ol derivatives to modulate protein kinases and for treating protein kinase-mediated diseases.
Claims16
A method of treating cancer in a mammal, wherein the cancer is selected from the group consisting of Chronic Myelogenous Leukemia (CIVIL), Acute Myelogenous Leukemia (AML) and thyroid, endometrial, gastric, breast and pancreatic carcinoma, and wherein the method comprises administering to the mammal a therapeutically effective amount of a composition comprising NTW-3475, wherein NTW-3475 is the compound having the structure:
A method for reducing signal transduction by the pERK pathway in cells comprising contacting the cells with NTW-3475, wherein the cells are MiaPaCa-2 cells or BxPC3 cells, and wherein NTW-3475 is the compound having the structure:
Dependencies are inferred from the claim text.