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US 10,245,256 B2Granted
Nitroxides for use in treating or preventing diabetes and obesity
AssigneeMitos Pharmaceuticals, Inc.
InventorsLouis Habash, Clarence Jones
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Abstract
Pharmaceutical compositions are provided that are useful in treating diabetes. The compositions comprise a pharmaceutically acceptable carrier, and an effective therapeutic or prophylactic amount of a nitroxide antioxidant that alters the expression of genes related to diabetes. Methods are also provided for the use of the pharmaceutical compositions in the treatment or prevention of diabetes. In a preferred embodiment, the nitroxide antioxidant is Tempol (4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl).
Claims15
A method of treatment comprising:
- identifying a subject having elevated TNFa levels, and
- administering to the subject an amount of a nitroxide antioxidant effective to reduce said levels in the subject, wherein the nitroxide antioxidant is selected from the following formulas:
- wherein X is selected from O— and OH, and R is selected from COOH, CONH2, CN, and CH2NH2;
- wherein X is selected from O— and OH, and R1 is CH3, R2 is C2H5, or R1 and R2 taken together are spirocyclohexyl;
- wherein X is selected from O— and OH and R is selected from CONH2;
- and
- wherein X is selected from O— and OH and R is selected from H, OH, and NH2, or wherein the nitroxide antioxidant is selected from the group consisting of 4-Oxo-2,2,6,6-tetramethylpiperidine-1-oxyl, 4-(2-bromoacetamido)-2,2,6,6-tetramethylpiperidine-1-oxyl, 4-(ethoxyfluorophosphonyloxy)-2,2,6,6-tetramethylpiperidine-1-oxyl, 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl, 4-(2-iodoacetamido)-2,2,6,6-tetramethylpiperidine-1-oxyl, 4-isothiocyanato-2,2,6,6-tetramethylpiperidine-1-oxyl, 4-maleimido-2,2,6,6-tetramethylpiperidine-1-oxyl, 4-(4-nitrobenzoyloxyl)-2,2,6,6-tetramethylpiperidine-1-oxyl, and 4-phosphonooxy-2,2,6,6-tetramethylpiperidine-1-oxyl.
4 more elements
Dependencies are inferred from the claim text.