Pharmaceutical compositions comprising nitroxyl donors
AssigneeCardioxyl Pharmaceuticals, Inc.
InventorsVincent Jacob Kalish, John Reardon, Frederick Arthur Brookfield, Stephen Martin Courtney, Lisa Marie Frost, John P. Toscano
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Abstract
The present disclosure provides nitroxyl donating pharmaceutical compositions comprising N-substituted hydroxylamine derivatives. The compositions are highly efficacious in treating cardiovascular diseases (e.g., heart failure), have a suitable toxicological profile, and are sufficiently stable for intravenous or oral administration.
Claims49
A pharmaceutical composition comprising a N-hydroxysulfonamide type nitroxyl donor and an aqueous buffer, wherein the N-hydroxysulfonamide type nitroxyl donor is a compound of the formula (1)
- and
- wherein the composition has a pH of from about 5 to about 6.5.
A pharmaceutical composition comprising a N-hydroxysulfonamide type nitroxyl donor and a cyclodextrin, wherein the N-hydroxysulfonamide type nitroxyl donor is a compound of the formula (1):
An admixture comprising a N-hydroxysulfonamide type nitroxyl donor and a cyclodextrin, wherein the molar ratio between the N-hydroxysulfonamide type nitroxyl donor and the cyclodextrin present in the composition is from about 0.02:1 to about 2:1;
- and wherein the N-hydroxysulfonamide type nitroxyl donor is a compound of the formula (1):
A pharmaceutical composition comprising a N-hydroxysulfonamide type nitroxyl donor and an aqueous buffer, wherein the N-hydroxysulfonamide type nitroxyl donor is a pharmaceutically acceptable salt of a compound of the formula (1)
- and
- wherein the composition has a pH of from about 5 to about 6.
A pharmaceutical composition comprising a N-hydroxysulfonamide type nitroxyl donor and a cyclodextrin, wherein the N-hydroxysulfonamide type nitroxyl donor is a pharmaceutically acceptable salt of a compound of the formula (1):
Dependencies are inferred from the claim text.