Compressed tablet containing cannabidiol, method for its manufacture and use of such tablet in oral treatment of psychosis or anxiety disorders

A compressed tablet having a tablet weight of 60-1200 mg and comprising:

• (a) 50-95 wt. % of a granulate;
• (b) 5-50 wt. % of lactose;
• and
• (c) 0-30 wt. % of other tablet excipients;
• wherein the granulate comprises:
• (i) 2-15 wt. % of cannabidiol;
• (ii) 2-30 wt. % of sucrose fatty acid mono-ester;
• (iii) 30-96 wt. % of lactose;
• and
• (iv) 0-25 wt. % of other granulate excipients,
• wherein the granulate is composed of granules comprising lactose particles that are held together by a solid dispersion comprising cannabidiol and sucrose fatty acid mono-ester and optionally other granulate excipients;
• and
• wherein the compressed tablet is obtained by:
• (a) providing a lactose powder;
• (b) combining the lactose powder with a granulation fluid comprising a solution of cannabidiol, sucrose fatty acid mono-ester and optionally other granulate excipients in an organic solvent;
• (c) removing the organic solvent by evaporation to produce a granulate;
• (d) mixing the granulate with lactose and optionally other tablet excipients to produce a tablet mixture;
• and
• (e) compressing the tablet mixture into a tablet.