Advanced detection of sepsis

A method of treating a subject likely to develop sepsis comprising the steps of:

• (a) obtaining a measurement at a plurality of time points, prior to laboratory confirmation of a clinically significant infection causative of sepsis, of an amount of a compound according to formula (I)
• or a salt or solvate thereof, wherein R is C10-C22 acyl, in fluid or tissue of a SIRS-positive subject;
• (b) obtaining a measurement at a plurality of time points, prior to laboratory confirmation of a clinically significant infection causative of sepsis, of one or more clinical markers of the SIRS-positive subject selected from the group consisting of respiratory rate, temperature, heart rate, systolic blood pressure, diastolic blood pressure, mean artery pressure, white blood cell count, monocyte count, lymphocyte count, granulocyte count, neutrophil count, immature neutrophil to total neutrophil ratio, platelet count, serum creatinine concentration, urea concentration, lactate concentration, glucose concentration, base excess, pO2 and HCO3− concentration;
• provided respiratory rate and temperature are measured, and
• (c) obtaining a measurement at a plurality of time points, prior to laboratory confirmation of a clinically significant infection causative of sepsis, of an amount of one or more biomarkers in fluid or tissue of the SIRS-positive subject selected from the group consisting of ACTH, activated partial thromboplastin, albumin, antithrombin III, bacterial DNA, carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), cell surface proteins CD-14 and CD-64, copeptin, C-reactive protein, cortisol, D-dimer, E-selectin, extra-hepatic arginase (ARG2), endotoxin, fibrin degrading products, high mobility group box 1 (HMGB1), HLA-DRA, interleukins IL-6, IL-8 and IL-10, LBP LPS-binding protein, plasminogen activator inhibitor-1, procalcitonin, protein C, protein S, prothrombin, soluble thrombomodulin, surface-bound tumor necrosis factor receptor I (sTNF-RI), surface-bound tumor necrosis factor receptor II (sTNF-RII), thrombin activatable fibrinolysis inhibitor, TRAF-interacting protein with a forkhead-associated domain (TIFA), triggering receptor expressed on myeloid cells 1, and tumor necrosis factor alpha (TNFα);
• (d) determining whether the SIRS-positive subject is likely to develop sepsis based on the measurements obtained in (a)-(c);
• and
• (e) administering an effective therapeutic intervention for sepsis to the SIRS-positive subject if the SIRS-positive subject is determined to be likely to develop sepsis based on the measurements obtained in (a)-(c).