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US 10,221,433 B2Granted
Microorganisms having putrescine productivity and process for producing putrescine using the same
AssigneeCj Cheiljedang Corporation
InventorsKyoung Min Lee, Hee Kyoung Jung, Young Lyeol Yang, Hye Won Um, Chang Gyeom Kim, Hong Xian Li, Su Jin Park, Jong Hyun Yoon, Baek Seok Lee, Sun Young Lee
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Abstract
The present invention relates to a recombinant microorganism capable of producing putrescine, in which the microorganism is modified to have enhanced NCgl2522 activity, thereby producing putrescine in a high yield, and a method for producing putrescine using the microorganism.
Claims10
A recombinant microorganism having enhanced putrescine productivity,
- wherein the recombinant microorganism comprises a modification that enhances expression of a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:
- 21 or 23 as compared to the expression in the same microorganism without the modification that enhances expression,
- wherein the microorganism further comprises a modification that enhances expression of a polynucleotide encoding an ornithine decarboxylase (ODC) as compared to the expression in the same microorganism without the modification that enhances expression,
- wherein the modification that enhances expression is transformation with an expression vector comprising the polynucleotide or replacing the promoter of the polynucleotide with a heterologous promoter.
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Dependencies are inferred from the claim text.