Optimized HIV envelope gene and expression thereof
AssigneeInternational AIDS Vaccine Initiative
InventorsChristopher L. Parks, Maoli Yuan, Xinsheng Zhang, Aaron Wilson, Angela Grazia Lombardo, Eddy Sayeed, Josephine Helena Cox, Takashi Hironaka, Makoto Inoue, Hiroto Hara
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Abstract
The present invention relates to a vector(s) containing and expressing an optimized HIV EnvF gene, methods for making the same and cell substrates qualified for vaccine production which may comprise vector(s) containing optimized HIV genes.
Claims10
A Sendai viral vector containing and expressing a nucleic acid encoding a Clade A Env-F hybrid based on BG505, wherein the Env signal sequence (SS), transmembrane region (TMR), and the cytoplasmic tail (CT) of HIV Env-F are replaced with an analogous sequence from the Sendai virus F gene, wherein the nucleic acid comprises the sequence of SEQ ID NO:
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A nucleic acid comprising the sequence of SEQ ID NO:
- 18.
Dependencies are inferred from the claim text.