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US 10,219,895 B2Granted
Nanofiber-based graft for heart valve replacement and methods of using the same
AssigneeWake Forest University Health Sciences
InventorsWilliam D. Wagner, Nicole Levi, Rui Wang, Louis C. Argenta, Michael J. Morykwas
Life of this patent
Estimating the term…
Abstract
Nanofiber-based biomaterials containing fibroin for wound repair and tissue replacement and, more particularly, heart valve replacement.
Claims29
A porous electrospun graft material configured to replace biological tissue, the electrospun graft material comprising a collagen, a fibroin, and a hemocompatible synthetic elastomer,
- wherein the hemocompatible synthetic elastomer is a polyglycerol derivative ester comprising a polycarboxylic acid, and
- wherein collagen comprises 45 wt. % of the total composition weight, fibroin comprises 45 wt. % of the total composition weight, and the polyglycerol derivative ester comprising a polycarboxylic acid comprises 10 wt. % of the total composition weight.
A porous electrospun graft material configured to replace biological tissue, wherein the porous electrospun graft material comprises collagen:
- fibroin:
- poly (glycerol sebacate) at 4.5:4.5:1 weight ratio.
Dependencies are inferred from the claim text.