TTField treatment with optimization of electrode positions on the head based on MRI-based conductivity measurements

A method of optimizing positions of a plurality of electrodes placed on a subject's body, wherein the electrodes are used to impose an electric field in target tissue within an anatomic volume, the method comprising the steps of:

• obtaining electrical conductivity or resistivity measurements in the anatomic volume;
• generating a 3D map of electrical conductivity or resistivity of the anatomic volume directly from the obtained electrical conductivity or resistivity measurements, without segmenting the anatomic volume into tissue types;
• identifying a location of the target tissue within the anatomic volume;
• and
• determining positions for the electrodes based on the 3D map of electrical conductivity or resistivity generated in the generating step and the location of the target tissue identified in the identifying step.