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AssigneeMitotech SA
InventorsMaxim Vladimirovich Skulachev, Vladimir Petrovich Skulachev, Maxim Viktorovich Egorov, Nikolai Konstantinovich Isaev, Nadezhda Anatolievna Kapay, Dmitry Borisovich Zorov, Elena Viktorovna Stelmashuk, Fedor Fedorovich Severin
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A method for providing to a mammal a neuroprotective effect against a brain pathology that is associated with reactive oxygen species originating from mitochondria (mROS). The method includes the step of administering to the mammal an SkQ mitochondria-targeted antioxidant in an amount effective to provide said neuroprotective effect. The SkQ mitochondria-targeted antioxidant may be administered either prophylactically or for treatment with respect to brain pathologies other than brain trauma or stroke, and may be administered for treatment of brain trauma or stroke.
A method for providing to a mammal a neuroprotective effect against a brain pathology that is mediated by reactive oxygen species originating from mitochondria (mROS), wherein the brain pathology is selected from the group consisting of alcohol intoxication, hyperhomocysteinemia, and brain trauma, the method comprising the step of administering to the mammal an SkQ mitochondria-targeted antioxidant in an amount effective to provide said neuroprotective effect, wherein the SkQ mitochondria-targeted antioxidant is administered either prophylactically to inhibit the course of the pathology or for treatment of the pathology after its onset with the exception that, where the pathology is brain trauma, the SkQ mitochondria-targeted antioxidant is administered only for treatment after onset of the pathology.
A method for providing to a mammal a neuroprotective effect against a brain pathology, wherein the brain pathology is brain trauma, the method comprising the step of administering to the mammal an SkQ mitochondria-targeted antioxidant in an amount effective to initiate an increased production of erythropoietin in the mammal.
A method for providing to a mammal a neuroprotective effect against a brain pathology, wherein the brain pathology is brain trauma, the method comprising the step of administering to the mammal an SkQ mitochondria-targeted antioxidant in an amount effective to cause a decrease in activity of glycogen synthase kinase (GSK-3β) in the mammal.
Dependencies are inferred from the claim text.