Virus like particle purification
AssigneeTakeda Vaccines, Inc.
InventorsThomas S. Vedvick, Bryan Steadman, Charles Richardson, Thomas R. Foubert, Charles R. Petrie
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Abstract
Methods for purifying human Calciviruses are disclosed, including Noroviruses and Sapoviruses.
Claims11
A composition comprising Norovirus genogroup II, genotype 4 (GII.4) virus-like particles (VLPs), wherein the composition is prepared by a method comprising contacting a solution containing said VLPs with at least one chromatographic material, wherein the at least one chromatographic material is an anion exchange chromatographic material, wherein the chromatographic materials used in the method do not comprise hydroxyapatite, and wherein the VLPs are present in the composition at a purity level of greater than about 90%.
Dependencies are inferred from the claim text.