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US 10,119,972 B2Granted
Reactive labelling compounds and uses thereof
AssigneeAcademia Sinica
InventorsChi-Huey Wong, Jim-Min Fang, Jiun-Jie Shie
Life of this patent
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Abstract
Provided are azido-BODIPY compounds of formula (I), cyclooctyne-based fluorogenic probes of formula (IV), and activity-based probes of formula (VI). These compounds undergo azide-alkyne cycloadditions (AAC) with to form triazolyl products. The provided compounds are useful for detection and imaging of alkyne-, or azide-containing molecules. Methods for detection and imaging biomolecules using compounds of the present disclosure are disclosed.
Claims7
A compound of formula (V) or (VI):
- wherein L is selected from the group consisting of umbelliferyl, coumarin oxide, triflate, mesylate, tosylate, alkoxy, phenoxy, benzoate, pentafluorophenoxy, or 4-nitrophenoxy.
Dependencies are inferred from the claim text.