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US 10,119,137 B2Granted
Methods used to treat cancer
AssigneeThe Translational Genomics Research Institute
InventorNhan Tran
Life of this patent
Estimating the term…
Abstract
The invention encompasses methods used in the sensitization and treatment of cancer based upon the expression of SGEF.
Claims13
A method of sensitizing a patient with glioblastoma to a radiation therapy and/or chemotherapy, the method comprising the steps of:
- administering to the patient with glioblastoma an src-homology 3 domain containing guanine nucleotide exchange factor (SGEF) inhibitor, wherein the SGEF inhibitor sensitizes the glioblastoma to the radiation therapy and/or chemotherapy, and wherein the SGEF inhibitor is a small hairpin RNA targeting the nucleic acid encoding for SGEF.
A method of treating a patient with invasive glioblastoma, the method comprising the steps of:
- a. sensitizing the patient with invasive glioblastoma by reducing an expression level of Src-homology 3 domain containing guanine nucleotide exchange factor (SGEF) using an SGEF inhibitor, wherein the SGEF inhibitor is a small hairpin RNA targeting the nucleic acid encoding for SGEF;
- and
- b. administering a therapeutically effective amount of a radiation therapy and/or chemotherapy to the patient with invasive glioblastoma.
A method of treating a patient with glioblastoma, the method comprising the steps of:
- a. sensitizing the patient with glioblastoma by reducing an expression level of Src-homology 3 domain containing guanine nucleotide exchange factor (SGEF) by administering to the patient a small hairpin RNA targeting SGEF;
- and
- b. administering a therapeutically effective amount of a radiation therapy and/or chemotherapy to the patient with glioblastoma.
Dependencies are inferred from the claim text.