US 10,119,135 B2 · Therapeutic micro RNA targets in chronic pulmonary diseases

Abstract

The present invention relates to the identification of microRNAs of the miR-148 family that are involved in the pathogenesis of chronic pulmonary diseases. The present invention relates to micro RNA of the miR-148 family selected from miR-148a, miR-148b and miR-152 for use in the diagnosis, prognosis, prevention and/or therapy of a chronic pulmonary disease. The present invention further relates to miR-148 inhibitors, pharmaceutical compositions comprising such inhibitors, their use in preventing and/or treating chronic pulmonary diseases, and methods for preventing and/or treating chronic pulmonary diseases. The present invention further relates to transgenic, non-human mammals and methods for identifying modulators of miR-148 and methods for diagnosis and/or prognosis of chronic pulmonary diseases.

Claims15

Dependent claims

A method of treating a chronic pulmonary disease selected from chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF) lung disease, in a subject in need thereof, the method comprising:

inhibiting a micro RNA 148b (miR-148b) expression and/or activity by administering to the subject an effective amount of at least one inhibitor of miR-148b, wherein the at least one inhibitor of miR-148b comprises a sequence complementary to at least 13 contiguous nucleotides of a nucleotide sequence of SEQ ID NO:1 or a sequence having at least 95% sequence identity to a nucleotide sequence of SEQ ID NO:1.

Dependencies are inferred from the claim text.

Facts

Application

14/402,586Filed 15 May 2013 · us provisional application

Priority

22 May 2012

Published

US 2015/0140067 A121 May 2015

Granted

6 Nov 2018

Term ends

Not estimatedThe source records don’t support an estimate.

Classification16 codes

C12N 15/113
DNA or RNA fragments; Modified forms thereof ; Non-coding nucleic acids having a biological activity: non-coding nucleic acids modulating the…
A61K 31/713
Compounds having three or more nucleosides or nucleotides: double-stranded nucleic acids or oligonucleotides
A61K 45/06
Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00: mixtures of active ingredients without…
A61K 47/543
The modifying agent being an organic compound: lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine

Therapeutic micro RNA targets in chronic pulmonary diseases

Life of this patent

Therapeutic micro RNA targets in chronic pulmonary diseases

Life of this patent

Abstract

Claims15