Long-acting coagulation factors and methods of producing same
AssigneeOPKO Biologics Ltd.
InventorsUdi Eyal Fima, Gili Hart
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Abstract
Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotrophin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions comprising the polypeptides and polynucleotides of the invention and methods of using and producing same are also disclosed.
Claims21
A method of treating hemophilia A in a subject, the method comprising administering a CTP-modified Factor VII (FVII) polypeptide to said subject, wherein said CTP-modified Factor VII (FVII) polypeptide consists of a coagulation Factor VII (FVII) polypeptide and three chorionic gonadotropin carboxy terminal peptides (CTPs) attached to the carboxy terminus of said coagulation FVII polypeptide, thereby treating said hemophilia A.
A method of treating hemophilia B in a subject, the method comprising the step of administering to the subject a CTP-modified Factor IX (FIX) polypeptide, wherein the CTP-modified Factor IX (FIX) polypeptide consists of a coagulation Factor IX (FIX) polypeptide and three chorionic gonadotrophin carboxy terminal peptides (CTPs) attached to the carboxy terminus of said coagulation FIX polypeptide, thereby treating said hemophilia B in said subject.
Dependencies are inferred from the claim text.