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AssigneeWuhan YZY Biopharma Co., Ltd.
InventorsPengfei Zhou, Jing Zhang, Lingli Hu, Rui Wang, Xiang Zhou, Kesu Fan
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The present invention provides a bispecific antibody. The bispecific antibody provided by the present invention comprises a single-chain unit and a monovalent unit, wherein the single-chain unit has a specific binding capability against a surface antigen CD3 of an immune cell; the monovalent unit has a specific binding capability against a surface antigen HER2 of a tumor cell; the single-chain unit comprises a single-chain variable fragment ScFv fused with an Fc fragment; and the monovalent unit comprises a light chain and heavy chain pair. The present invention also provides a preparation method of the bispecific antibody and pharmaceutical use of these antibodies.
A bispecific antibody comprising:
A method of treating a human cancer patient having a tumor cell characterized with a tumor cell membrane surface antigen comprising administering to the patient a bispecific antibody comprising (a) a monovalent unit comprising a light chain-heavy chain pair having specificity to the tumor cell membrane surface antigen;
Dependencies are inferred from the claim text.