Back to results
US 10,118,960 B2Granted
Humanized antibodies that recognize alpha-synuclein
AssigneeProthena Biosciences Limited
InventorsJose Saldanha, Tarlochan S. Nijjar
Life of this patent
Estimating the term…
Abstract
The present application discloses humanized 1H7 antibodies. The antibodies bind to human alpha synuclein and can be used for treatment and diagnosis of Lewy body disease.
Claims22
An antibody comprising a mature heavy chain variable region comprising the three Kabat CDRs of SEQ ID NO:
- 44, and being at least 90% identical to SEQ ID NO:
- 44, and a mature light chain comprising the three Kabat CDRs of SEQ ID NO:
- 45, and being at least 90% identical to SEQ ID NO:
- 45, wherein:
- (a) position L46 (Kabat numbering) is occupied by F, position L49 (Kabat numbering) is occupied by C and position L83 (Kabat numbering) is occupied by A;
- or (b) position H67 (Kabat numbering) is occupied by A and position H71 (Kabat numbering) is occupied by A.
3 more elements
Dependencies are inferred from the claim text.