Method for treating heart disease by inhibiting the Coxsackievirus-Adenovirus Receptor
AssigneeMax-DelbrüCk-Centrum FüR Molekulare Medizin (Mdc) Berlin-Buch
InventorsMichael Gotthardt, Fabian Freiberg
Life of this patent
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Abstract
The invention pertains to a means for downregulating or inhibiting or mislocalizing CAR in a cardiac cell for treating/curing a patient who has suffered or is predisposed to suffering a myocardial infarction (MI) or preventing myocardial infarction or complications thereof.
Claims5
A method for down-regulating or inhibiting Coxsackievirus-Adenovirus Receptor (CAR) in a heart of a subject not suffering from myocarditis, comprising administering to the subject at least one of:
- a CAR protein ligand or a CAR protein ligand fragment, wherein the heart is a heart subjected to inadequate perfusion.
A method for down-regulating or inhibiting Coxsackievirus-Adenovirus Receptor (CAR) in a cardiac cell of a subject not suffering from myocarditis, comprising:
- functionally inhibiting a CAR protein by administering to the subject a CAR protein ligand, wherein the cardiac cell is a cardiac cell subjected to inadequate perfusion.
A method for down-regulating or inhibiting Coxsackievirus-Adenovirus Receptor (CAR) in a heart of a subject not suffering from myocarditis, comprising administering to the subject at least one of:
- a CAR protein ligand or a CAR protein ligand fragment, wherein the heart is a heart subjected to ischemia.
Dependencies are inferred from the claim text.