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US 10,118,953 B2Granted
Glucocorticoid-induced tumor necrosis factor receptor ligand (GITRL) single-chain fusion polypeptides
AssigneeApogenix AG
InventorsOliver Hill, Christian Gieffers, Meinolf Thiemann
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Abstract
The present invention refers to single-chain fusion proteins comprising three soluble TNF superfamily (TNFSF) cytokine domains and nucleic acid molecules encoding these fusion proteins. The fusion proteins are substantially non-aggregating and suitable for therapeutic, diagnostic and/or research applications.
Claims13
A single-chain fusion polypeptide comprising:
- (i) a first soluble glucocorticoid-induced tumor necrosis factor receptor ligand ligand (GITRL) cytokine domain,
- (ii) a first peptide linker,
- (iii) a second soluble GITRL cytokine domain,
- (iv) a second peptide linker, and
- (v) a third soluble GITRL cytokine domain,
- wherein each of the soluble GITRL cytokine domains lacks a stalk region and the first and the second peptide linkers independently have a length of 3-8 amino acids.
3 more elements
Dependencies are inferred from the claim text.