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US 10,118,949 B2Granted
Compositions, methods and uses
AssigneeAffibody AB
InventorsLars Abrahmsén, Andreas Jonsson, Jakob Dogan, Per-Åke Nygren
Life of this patent
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Abstract
The present invention relates to a class of engineered polypeptides having a binding affinity for albumin. It also relates to new methods and uses that exploit binding by these and other compounds to albumin in different contexts, some of which have significance for the treatment of disease in mammals including humans.
Claims20
An engineered albumin binding polypeptide comprising SEQ ID NO:266, SEQ ID NO:
- 272, SEQ ID NO:
- 282, SEQ ID NO:
- 284, SEQ ID NO:
- 306, SEQ ID NO:
- 496, or SEQ ID NO:
- 500;
- or the amino acid sequence having 93% or greater identity to the full-length sequence of SEQ ID NO:266, SEQ ID NO:
- 272, SEQ ID NO:
- 282, SEQ ID NO:
- 284, SEQ ID NO:
- 306, SEQ ID NO:
- 496, or SEQ ID NO:
- 500:
- wherein the albumin binding polypeptide binds to human serum albumin such that the KD value of the interaction is at most 1×10−9 M.
11 more elements
Dependencies are inferred from the claim text.