Melampomagnolide B dimers
AssigneesBioVentures, LLC, The Regents of the University of Colorado
InventorsVenumadhav Janganati, Peter Crooks, Narsimha Reddy Penthala, Craig Jordan, Shobanbabu Bommagani, Jessica Ponder
Life of this patent
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Abstract
The present disclosure provides dimers of melampomagnolide B (MMB), including carbamate, carbonate, succinic amide, ester and carboxamide dimers of MMB. These derivatives are useful for treating cancer in humans, in particular in treating leukemia, including acute myelogenous leukemia (AML).
Claims17
A method for treating cancer, comprising administering a therapeutically effective amount of a compound comprising Formula (I), or a pharmaceutically acceptable salt thereof, to a patient in need thereof, according to the following formula:
- wherein:
- Z is independently selected from the group consisting of CH2, O, C(O), and CH, wherein when Z is CH, Z is connected to Y via a double bond and Y is N;
- Y is independently selected from the group consisting of O, NR, N,
- heterocycle, hydrocarbyl and substituted hydrocarbyl;
- X is selected from the group consisting of (CH2)n, C(O),
- —(CH2)n—W—C(O)—, —C(O)—W—C(O)—, —C(O)NH—W—NHC(O)—, —C(O)O—W—OC(O)—, carbocycle, heterocycle, alkyl, substituted alkyl, hydrocarbyl and substituted hydrocarbyl;
- R is selected from the group consisting of H, alkyl, hydrocarbyl and substituted hydrocarbyl;
- W is selected from the group consisting of O, S, NH, N-alkyl, heterocycle, alkyl, substituted alkyl, hydrocarbyl and substituted hydrocarbyl;
- and
- n is an integer from 0-10.
A method for inhibiting growth of a cancer cell, the method comprising contacting the cancer cell with an amount of a compound comprising Formula (I), or a pharmaceutically acceptable salt thereof, effective to inhibit growth of the cancer cell, the compound comprising Formula (I):
- wherein:
- Z is independently selected from the group consisting of CH2, O, C(O), and CH, wherein when Z is CH, Z is connected to Y via a double bond and Y is N;
- Y is independently selected from the group consisting of O, NR, N,
- heterocycle, hydrocarbyl and substituted hydrocarbyl;
- X is selected from the group consisting of (CH2)n, C(O),
- —(CH2)n—W—C(O)—, —C(O)—W—C(O)—, —C(O)NH—W—NHC(O)—, —C(O)O—W—OC(O)—, carbocycle, heterocycle, alkyl, substituted alkyl, hydrocarbyl and substituted hydrocarbyl;
- R is selected from the group consisting of H, alkyl, hydrocarbyl and substituted hydrocarbyl;
- W is selected from the group consisting of O, S, NH, N-alkyl, heterocycle, alkyl, substituted alkyl, hydrocarbyl and substituted hydrocarbyl;
- and
- n is an integer from 0-10.
Dependencies are inferred from the claim text.