Piperidinylpyrazolopyrimidinones and their use

Compound of formula (I-B)

• in which
• R1 is selected from the group consisting of hydrogen, and C1-C5 alkyl;
• R2 is selected from the group consisting of hydrogen, C1-C4 alkyl, C3-C6 cycloalkyl, C1-C4 haloalkyl, carboxyl, C1-C4 alkylester, C1-C4 alkoxy-C1-C4 alkyl, halogen, methylsulfanyl, phenyl, the phenyl being optionally substituted with halogen, and 5 membered heteroaryl;
• R3 is selected from the group consisting of hydrogen, halogen, cyano, C1-C4 alkyl, the alkyl being optionally substituted with di-C1-C4 alkylamino, C1-C4 alkenyl, C1-C4 alkylester, the C1-C4 alkylester being optionally substituted with one, two, three, four, or five halogen substituents, C3-C4 cycloalkylester, C3-C4 cycloalkyl, carboxyl, carboxamide, benzylester, —NH—CO-phenyl, —CS—NH2,
• phenylsulfonyl, the phenylsulfonyl being optionally substituted with one, two, or three halogen substituents,
• phenyl,
• the phenyl being optionally substituted with one, two, or three substituents selected from the group consisting of halogen and C1-C4 alkoxy, where two adjacent methoxy groups may optionally form a dioxane ring,
• or the phenyl being optionally substituted with one or two substituents selected from the group consisting of C1-C4 alkyl, C1-C4 haloalkyl, C1-C4 haloalkoxy, cyano, benzyloxy, methylsulfonyl, and phenyl, the phenyl being optionally substituted with C1-C4 haloalkyl,
• 5-6 membered heterocyclyl-C1-C4 alkyl, the 5-6 membered heterocyclyl-moiety being optionally substituted with one, two, or three substituents selected from the group consisting of C1-C4 alkyl and oxo,
• 5-6 membered heteroaryl,
• the 5-6 membered heteroaryl being optionally substituted with one, two, or three substituents selected from the group consisting of C1-C6 alkyl, C2-C6 alkenyl, C1-C6 haloalkyl, C1-C4 aminoalkyl, C1-C4 alkylester, C1-C4 alkoxy, C1-C4 haloalkoxy, C1-C4 alkoxy-C1-C4 alkyl, cyano, hydroxyl, carboxyl, C1-C4 alkyl-SO2—C1-C4 alkyl, and —CO—NH2,
• or the 5-6 membered heteroaryl being optionally substituted with one C3-C6 cycloalkyl substituent, the C3-C6 cycloalkyl optionally being substituted with one, two, or three halogen or methyl substituents, or with phenyl, the phenyl being optionally substituted with C1-C4 alkoxy or halogen,
• or the 5-6 membered heteroaryl being optionally substituted with one substituent selected from the group consisting of fused or bridged C5-C12 bi- or tricycloalkyl, C3-C6 cycloalkyl-C1-C4 alkyl, C3-C6 cycloalkyl-C1-C4 alkenyl, phenyl, the phenyl optionally being substituted with one, two, or three substituents selected from the group consisting of C1-C4 alkyl, halogen, C1-C4 haloalkyl, C1-C4 alkoxy, C1-C4 haloalkoxy, C1-C4-alkylester, nitro, amino, di-C1-C4 alkylamine, and cyano,
• phenyl-C1-C4 alkyl,
• the phenyl moiety optionally being substituted with one, two, or three substituents selected from the group consisting of halogen, C1-C4 alkyl, C1-C4 haloalkyl, C1-C4 alkoxy, C1-C4 haloalkoxy, and hydroxyl,
• the alkyl moiety optionally being substituted with one or two substituents selected from the group consisting of C1-C4 alkyl and hydroxyl,
• 5-6 membered heterocycloalkyl, the 5-6 membered heterocycloalkyl being optionally substituted with C3-C6 cycloalkyl or C1-C4 alkyl,
• 5-6 membered heterocycloalkyl-C1-C4 alkyl,
• the 5-6 membered heterocycloalkyl moiety being optionally substituted with C1-C4 alkyl or oxo,
• the C1-C4 alkyl moiety being optionally substituted with C1-C4 alkyl,
• 5-6 membered heteroaryl, the 5-6 membered heteroaryl being optionally substituted with one, two, or three substituents selected from the group consisting of halogen, C1-C4 alkyl, and C1-C4 haloalkyl,
• and 5-6 membered heteroaryl-C1-C4 alkyl,
• the 5-6 membered heteroaryl-moiety being optionally substituted with one or two substituents selected from the group consisting of C1-C4 alkoxy and C1-C4 alkyl,
• the C1-C4 alkyl-moiety being optionally substituted with one or two methyl substituents,
• —CO—R4, with R4 being selected from the group consisting of C1-C4 alkyl, wherein the C1-C4 alkyl is optionally substituted with one or two methyl, and C3-C6 cycloalkyl,
• —CO—N(R5R7), with
• R5 being selected from the group consisting of hydrogen and C1-C4 alkyl,
• R7 being selected from the group consisting of hydrogen, C1-C6 alkyl, C1-C6 haloalkyl, C1-C4-alkoxy-C1-C4 alkyl, amino-oxo-C1-C4 alkyl, naphthyl,
• C3-C6 cycloalkyl, the C3-C6 cycloalkyl being optionally substituted with one or two C1-C4 alkyl substituents,
• C3-C6 cycloalkyl-C1-C4 alkyl,
• 5-6 membered heterocyclyl,
• oxazolidinyl-C1-C4 alkyl,
• benzyl,
• the phenyl moiety of the benzyl being optionally substituted with one, two, or three C1-C4 alkyl substituents,
• the methyl moiety of the benzyl optionally being substituted with C1-C4 alkyl,
• benzyl-C3-C6 cycloalkyl,
• imidazolyl-C1-C4 alkyl, the imidazolyl-C1-C4 alkyl being optionally substituted with one, two, or three C1-C4 alkyl substituents,
• oxazolyl-C1-C4 alkyl, the oxazolyl-C1-C4 alkyl being optionally substituted with one, two, or three C1-C4 alkyl substituents,
• oxazolidinone-C1-C4 alkyl,
• pyridinyl-C1-C4 alkyl,
• and phenyl, the phenyl being optionally substituted with one, two, or three substituents selected from the group consisting of C1-C4 alkyl, halogen, and C1-C4 alkoxy,
• or —N(R5R7) being selected from the group consisting of 5-7 membered cyclic amines which contain one or two ring nitrogen atoms, zero or one ring oxygen atom, and zero or one ring sulfur atom, and are attached via a ring nitrogen atom, the 5 to 7 membered cyclic amines being optionally substituted with one, two, or three substituents selected from the group consisting of C1-C4 alkoxy, C1-C4 alkoxy C1-C4 alkyl, oxo, hydroxyl, halogen, and C1-C4 alkyl,
• or —N(R5R7) being selected from the group consisting of two annelated, aromatic, partially saturated or saturated rings which are each 5-7 membered and each contain one or two ring nitrogen atoms and are attached via a ring nitrogen atom,
• and —N(R5R7) being selected from the group consisting of bicyclic azaspiro compounds, the azaspiro compounds being optionally substituted with oxo;
• or R2 and R3 together form a C5-C6 cycloalkyl ring;
• or a salt of the compound, or a solvate of the compound, or a solvate of the salt thereof.