Treatment of H. pylori infections using MTAN inhibitors
AssigneesAlbert Einstein College of Medicine, Victoria Link Limited
InventorsVern L. Schramm, Keith Clinch, Shivali Ashwin Gulab
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Abstract
Methods of treating infections due to Helicobacter pylori (H. pylori), in particular in subjects having a peptic ulcer, are disclosed where the methods comprise administering inhibitors of H. pylori MTAN (5′-methylthioadenosine nucleosidase) to the subject, where the inhibitors have the structure
Claims22
A method of treating a Helicobacter pylori (H. pylori) infection in a subject comprising administering to the subject a compound in an amount effective to inhibit growth of H. pylori, wherein the compound has the formula
- wherein R is Q or CH2SQ1, wherein Q is C1-C9 alkyl, aryl, heteroaryl, aralkyl, or C4-C7 cycloalkyl, where Q is optionally substituted with one or more halogen, OH and/or NH2 groups, and wherein Q1 is C4-C9 alkyl, aryl, heteroaryl, aralkyl, or C4-C7 cycloalkyl, where Q1 is optionally substituted with one or more halogen, OH and/or NH2 groups,
- or a pharmaceutically acceptable salt thereof, or an ester thereof.
A method of treating a Helicobacter pylori (H. pylori) infection in a subject comprising administering to the subject a compound in an amount effective to inhibit growth of H. pylori, wherein the compound is selected from the group consisting of
- or a pharmaceutically acceptable salt thereof, or an ester thereof.
Dependencies are inferred from the claim text.