Substituted piperidin-4-amino-type compounds and uses thereof

A compound of Formula (I):

• or a pharmaceutically acceptable salt or solvate thereof, wherein:
• Q1 is phenyl;
• Q2 is (C3-C10)cycloalkyl, (3- to 9-membered)non-aromatic heterocycle, or a direct bond;
• E1 is S(═O)2 or a direct bond;
• E2 is C(═O), S(═O)2, CH2, or a direct bond;
• W is N(R*) or a direct bond;
• D is H, NO2, or N(R*)2;
• R* is, independently for each occurrence, H or (C1-C6)alkyl unsubstituted or substituted with 1 or 2 substituents independently selected from —OH, —O(C1-C6)alkyl, and ═O;
• each R2 and R3 is, independently for each occurrence, —H, -halo, —NO2, —X, —C(═Y)YX, —N(T1)(T2), —YH, or —YX;
• X is, independently for each occurrence, —H, —(C1-C6)alkyl, —(C2-C6)alkenyl, or -(5- or 6-membered)heterocycle, each of which is unsubstituted or substituted with 1 or 2 independently selected R8 groups;
• each Y is O;
• each R5 is independently OR9 or ═O;
• each R8 is independently —OR9, ═O, or —C(═O)OR9;
• each R9 is independently —H or —(C1-C6)alkyl;
• a is an integer selected from 0 and 1;
• b is an integer selected from 0 and 1;
• n is an integer selected from 0 and 1;
• x is an integer selected from 0 and 1;
• each T1 and T2 is independently —H or —(C1-C10)alkyl which is unsubstituted or substituted with 1, 2, or 3 independently selected R5 groups;
• A and B together form a bridge such that the bridged-piperidine is:
• and
• —Z—R1 is:
• wherein each Rz is independently —H, —(C1-C4)alkyl, —OH, or —CN.