Heterocyclic modulators of lipid synthesis

A compound of Structure IIIb:

• IIIb, or pharmaceutically acceptable salts thereof, wherein:
• L-Ar is
• or
• Ar is
• Het is a 5- to 6-membered heteroaryl;
• R1 is H, —CN, halogen, C1-C4 alkyl, O(C3-C5 cycloalkyl), O-(4- to 6-membered heterocycle) or O(C1-C4 alkyl), wherein when R1 is not H, —CN or halogen, R1 is optionally substituted with one or more halogens;
• each R2 is independently hydrogen, halogen or C1-C4 alkyl;
• R3 is H or F;
• R11 is H or CH3;
• R21 is H, halogen, C1-C4 alkyl, C3-C5 cycloalkyl or 4- to 6-membered heterocycle;
• R22 is H, halogen or C1-C2 alkyl;
• and
• each R24 and R25 is independently H, halogen, —CN, (C1-C4 alkyl)-CN, C1-C4 alkyl, (C1-C4 alkyl)-OH, (C1-C4 alkyl)-N(R241)2, (C1-C4 alkyl)1-O(C3-C5 cycloalkyl), (C1-C4 alkyl)t-Ou-(4- to 6-membered heterocycle) or (C1-C4 alkyl)t-O(C1-C4 alkyl),
• wherein:
• each t is independently 1:
• each u is independently 0 or 1;
• and
• each R241 is independently H or C1-C2 alkyl,
• wherein the compound is not: