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OwnerMing-Jen Cheng, Ping-Hsun Yang +6inventors
InventorsMing-Jen Cheng, Ping-Hsun Yang, Ming-Der Wu, Shie-Jea Lin, Gwo-Fang Yuan, Yen-Lin Chen, Hsuen-Chun Liao, Kai-Ping Chen
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The present invention relates to a monascuspurpurone compound of formula (I): or a pharmaceutically acceptable derivative thereof as described in the specification, the process for preparation of the same, and the composition comprising the same. The uses of a monascuspurpurone compound for promoting adipocyte differentiation, for increasing the activity of PPARγ and/or C/EBPα, for lowering blood glucose, for preventing and/or treating a disease or disorder related to insulin resistance, and for preventing and/or treating metabolic syndrome or its complications are also provided.
A method for preventing and/or treating a disease or disorder related to insulin resistance in a subject, which comprises administering to said subject a composition consisting of an effective amount of rel-(1S,7aR,3aR)-1-hexanoyl-5,13-dimethyl-6-(2-oxopentyl)-7a,7-dihydrobenzofuran-2,4-dione or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier or excipient.
A method of increasing the activity of PPARγ and/or C/EBPα in a subject in need thereof, which comprises administering to said subject a composition consisting of an effective amount of rel-(1S,7aR,3aR)-1-hexanoyl-5,13-dimethyl-6-(2-oxopentyl)-7a,7-dihydrobenzofuran-2,4-dione or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier or excipient.
A method of lowering blood glucose in a subject, which comprises administering to said subject a composition consisting of an effective amount of rel-(1S, 7aR,3aR)-1-hexanoyl-5,13-dimethyl-6-(2-oxopentyl)-7a,7-dihydrobenzofuran-2,4-dione or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier or excipient.
A method of preventing and/or treating metabolic syndrome or its complication in a subject, which comprises administering to said subject a composition consisting of an effective amount of rel-(1S,7aR,3aR)-1-hexanoyl-5,13-dimethyl-6-(2-oxopentyl)-7a,7-dihydrobenzofuran-2,4-dione or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier or excipient.
Dependencies are inferred from the claim text.