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US 10,118,901 B2Granted
Therapeutic agents
AssigneePurdue Pharmaceutical Products L.P.
InventorsYu Chen, Yi Chen
Life of this patent
Estimating the term…
Abstract
The present invention relates to a class of hydroxamic acid compounds of Formula (I), which act as alkylating agents and/or inhibitors of the HDAC pathway, having potential utility in the treatment of a neoplastic disease and immune diseases.
Claims17
A compound of Formula (I) or an N-oxide thereof, or a pharmaceutically acceptable salt of said compound of formula (I) or N-oxide thereof:
- wherein
- Z is (CRaRb)pN(Ra)(CRaRb)q;
- X1 and X2 are each independently selected from halo and OSO2Rc;
- P is
- Q is benzimidazolyl, which is optionally substituted with alkyl, alkenyl, alkynyl, cycloalkyl, halo, nitro, oxo, cyano or ORe;
- Ra, Rb, Rd and Re are each independently selected from H, alkyl, alkenyl and alkynyl;
- Rc is selected from alkyl, alkenyl and alkynyl;
- and
- p and q are each independently selected from 1, 2, 3 and 4.
6 more elements
Dependencies are inferred from the claim text.