US 10,118,899 B2 · Production method of enzalutamide crystal form

Abstract

The present invention aims to provided a novel production method of an enzalutamide crystal form in which wet crystals of enzalutamide are obtained in a step of crystallizing in the production process of the enzalutamide crystal form, and then 2-propanol which is solvated with enzalutamide and the B-type crystals are reduced. The present invention relates to a production method of an enzalutamide crystal form, which comprises a step of crystallizing for obtaining wet crystals of enzalutamide, and a step of drying the wet crystals, and comprises a step of washing using a mixed solvent of a good solvent and a poor solvent after the step of crystallizing.

Claims1

Dependent claims

A method of producing a crystal form of enzalutamide:

comprising a step of crysallizing for obtaining wet crystals of enzalutamide and a step of drying the wet crystals, wherein the method comprises a step of washing using a mixed solvent of a good solvent and a poor solvent after the step of crystallizing, wherein the good solvent is isopropyl acetate and the poor solvent is n-heptane.

Dependencies are inferred from the claim text.

Facts

Application

15/577,007Filed 27 May 2016

Priority

JP 2015-10980529 May 2015

Published

US 2018/0148417 A131 May 2018

Granted

6 Nov 2018

Term ends

Not estimatedThe source records don’t support an estimate.

Classification9 codes

C07D 233/86
With hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals,…:…
A61P 35/00
Antineoplastic agents
C07C 331/28
Isothiocyanates: having isothiocyanate groups bound to carbon atoms of six-membered aromatic rings
C30B 7/00
Single-crystal growth from solutions using solvents which are liquid at normal temperature

Production method of enzalutamide crystal form

Life of this patent

Production method of enzalutamide crystal form

Life of this patent

Abstract

Claims1