Antagonists of the kappa opioid receptor

A compound according to formula I

• or stereoisomers, tautomers, solvates, and/or salts thereof;
• wherein
• G1 and G2 are each independently C═O or S(O)2;
• R1, R2, R3, R4, R5, R7, R8, R9, R10, and R11 are each independently H, halo, hydroxy, amino, cyano, trifluoromethyl, thiol, alkylthio, sulfoxide, sulfone, nitro, pentafluorosulfanyl, carboxylate, amide, ester, or a substituted or unsubstituted C1-C6 alkyl, C1-C6 alkoxy, aryl, aryloxy, C1-C6 alkanoyl, C1-C8 alkanoyloxy, aryloyl, or aryloyloxy group, where any two adjacent R1, R2, R3, R4, R5, R7, R8, R9, R10, and R11 may join to form a 5-membered or 6-membered substituted or unsubstituted heteroalkyl group;
• R6 is a branched C1-C8 alkyl group or a substituted or unsubstituted cycloalkyl or aryl group;
• and
• R12 and R13 are each independently H or a substituted or unsubstituted C1-C8 alkyl or C5-C7 cycloalkyl group;
• and
• n is 0, 1, or 2;
• provided that when G1 is S(O)2, G2 is C═O, R1, R2, R4, R5, R7, R8, R9, R10, R11, R12, R13 are each H, R6 is isopropyl, and n is 1, then R3 is not methyl.