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US 10,118,894 B2Granted
Isoindolinone derivatives useful as antiviral agents
AssigneeViiV Healthcare UK Limited
InventorsBrian Alvin Johns, Emile Johann Velthuisen, Jason Gordon Weatherhead
Life of this patent
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Abstract
Compounds of Formula I are disclosed and methods of treating viral infections with compositions comprising such compounds.
Claims9
A compound of Formula I:
- or a pharmaceutically acceptable salt thereof wherein:
- R1 is C1-6 alkyl;
- R2 is C5-14aryl, C3-7cycloalkyl, (C3-7)cycloalkenyl, (C2-9)heterocycle, or (C2-9)heteroaryl, each of which is optionally substituted by one to four substituents selected from halo, C1-6 alkyl, C1-6 hetereoalkyl, or C1-6 alkylene or C1-6 hetereoalklylene wherein said C1-6alkylene or C1-6 hetereoalklylene are bonded to adjacent carbon atoms on said C5-14 aryl, C3-7cycloalkyl, (C3-C7)cycloalkenyl, (C2-C9)heterocycle, or (C2-C9)heteroaryl to form a ring, and wherein each heterocycle, heteroaryl, heteroalkyl, and hetereoalkylene contains one to three heteroatoms selected from S, N or O;
- L is a bond or C1-3 alkylene:
- and
- R3 is H, C1-6 alkyl, C5-14aryl, C3-7cycloalkyl, (C3-7)cycloalkenyl, (C2-9)heterocycle, or (C2-9)heteroaryl, each of which is optionally substituted by one to four substituents selected from halo, or C1-6 alkyl, and wherein each heterocycle and heteroaryl contains one to three heteroatoms selected from S, N or O.
3 more elements
Dependencies are inferred from the claim text.