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AssigneesThe University of Chicago, The University of North Carolina at Chapel Hill
InventorsWenbin Lin, Joseph M. Falkowski, Takahiro Sawano
Estimating the term…
Metal-organic framework (MOFs) compositions based on chiral phosphine-, chiral oxazoline-, chiral pyridine-, and chiral diene-derived organic bridging ligands were synthesized and then post-synthetically metalated with metal precursors such as Ru and Rh complexes. The metal complexes could also be directly incorporated into the MOFs. The MOFs provide a versatile family of recyclable and reusable single-site solid catalysts for catalyzing a variety of asymmetric organic transformations, including the addition of arylboronic acids to α,β-unsaturated ketones and alkimines, the hydrogenation of substituted alkene and carbonyl compounds, and cyclization reactions. The solid catalysts can also be integrated into a flow reactor or a supercritical fluid reactor.
An asymmetric heterogeneous catalyst comprising a crystalline and porous metal-organic framework (MOF), wherein said crystalline and porous MOF comprises periodic repeats of a coordination complex comprising (a) a metal-based secondary building unit (SBU), wherein said metal-based SBU comprises a first metal, and (b) a chiral bridging ligand, wherein said chiral bridging ligand is coordinatively bonded to more than one SBU, wherein said chiral bridging ligand is further complexed to a second metal to provide a catalytic moiety, and wherein said chiral bridging ligand is a dicarboxylate-substituted chiral bisphosphine or a dicarboxylate-substituted chiral bicyclo[2.2.2]octane-2,5-diene.
Dependencies are inferred from the claim text.