Microvascular obstruction detection and therapy

A system for treating a thrombotic or spasmodic obstruction in microvasculature with a treatment agent, the system comprising:

• an injector;
• an expandable occlusion member;
• an intravascular treatment catheter at least partially surrounded by the expandable occlusion member, the intravascular treatment catheter comprising a proximal portion in fluid communication with the injector, said intravascular treatment catheter comprising at least two lumens in communication with the proximal portion, and a distal diffusion portion, wherein the at least two lumens comprise:
• a first lumen configured to deliver inflation medium from the proximal portion of the intravascular treatment catheter to the expandable occlusion member disposed at a distal portion of the intravascular treatment catheter so as to selectively inflate and deflate the expandable occlusion member, said expandable occlusion member being positioned proximal to the distal diffusion portion of the intravascular treatment catheter;
• and
• a second lumen configured to fluidly communicate delivery of the treatment agent from the injector to the distal diffusion portion of the treatment catheter, said distal diffusion portion defining a plurality of small holes located distally of the expandable occlusion member, and configured to diffuse the treatment agents into the vasculature;
• wherein the distal tip of the intravascular treatment catheter comprises a distal port in communication with the second lumen to allow passage of a guidewire to position the intravascular catheter in the vasculature, said distal port being configured to allow passage of the guidewire through the distal tip, but sufficiently restrict the injection of treatment agent out of the distal port;
• and
• a sensor for monitoring the status of thrombotic or spasmodic occlusion of the microvasculature.