Microfluidic intravital window

A microfluidic intravital window, comprising:

• an intravital imaging window adapted for implantation with an inner surface of the intravital window adjacent target tissue of a live animal;
• and
• a microfluidic fluid source and delivery system physically integrated with the window for controlled delivery of fluid to the target tissue via the window, wherein the microfluidic fluid source and delivery system is self-contained and completely located on the inner surface of the intravital imaging window and includes at least one preloaded fluid reservoir, at least one fluid port in fluidic communication with both the at least one preloaded fluid reservoir and the target tissue, and at least one light activated fluid flow control device situated between the at least one preloaded fluid reservoir and the at least one fluid port, whereby simultaneous in vivo viewing and light controlled fluid delivery to the target tissue are facilitated.