US 10,117,956 B2 · Radiolabeled active targeting pharmaceutical composition and the use thereof

Abstract

The present invention is related to a radiolabeled active targeting pharmaceutical composition, including: a bioconjugate and a radionuclide, wherein the bioconjugate includes a biomolecule and a metal nanoparticle, wherein the biomolecule has an affinity for receptors on the surface of a cell membrane and is selected from the group consisting of a peptide and a protein. The present invention further provides a method for evaluating a thermal adjuvant therapy for tumors and a kit thereof. The above-mentioned pharmaceutical composition is applied to evaluate a tumor accumulation time, so as to establish the optimal policy for a radiofrequency- or laser-induced thermal adjuvant therapy for tumors.

Claims2

Dependent claims

A radiolabeled active targeting pharmaceutical composition, comprising:

a bioconjugate, comprising a peptide, a metal nanoparticle, and an intercalating agent, wherein the peptide is a Bombesin (BBN) peptide combined with maleimido-lipoamide, the intercalating agent is diethylene triamine pentaacetic acid (DTPA), and the metal nanoparticle is Au nanoparticle;
and
a radionuclide, selected from the group consisting of:
indium, iodine, lutetium, rhenium, gallium, and yttrium.

1 more element

Dependencies are inferred from the claim text.

Facts

Application

15/704,378Filed 14 Sep 2017 · division

Priority

TW 102133825 A18 Sep 2013

Published

US 2018/0117188 A13 May 2018

Granted

6 Nov 2018

Term ends

Not estimatedThe source records don’t support an estimate.

Classification7 codes

A61K 51/1093
Antibodies or immunoglobulins; Fragments thereof , the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised…
A61K 51/088
Peptides, e.g. proteins , carriers being peptides, polyamino acids, proteins: conjugates with carriers being peptides, polyamino acids or proteins
A61K 51/103
Against receptors, cell-surface antigens or cell-surface determinants: against receptors for growth factors or receptors for growth regulators
A61K 51/1244
Particles, powders, lyophilizates, adsorbates, e.g. polymers or resins for adsorption or ion-exchange resins: microparticles or nanoparticles,…

Radiolabeled active targeting pharmaceutical composition and the use thereof

Life of this patent

Radiolabeled active targeting pharmaceutical composition and the use thereof

Life of this patent

Abstract

Claims2