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US 10,117,950 B2Granted
Compounds and compositions for the treatment of ocular disorders
AssigneeGraybug Vision, Inc.
InventorsJeffrey L. Cleland, Ming Yang, John G. Bauman, Nu Hoang, Emmett Cunningham
Life of this patent
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Abstract
The disclosure describes prodrugs and derivatives of prostaglandins, carbonic anhydrase inhibitors, kinase inhibitors, beta-adrenergic receptor antagonists and other drugs, as well as controlled delivery formulations containing such prodrugs and derivatives, for the treatment of ocular disorders.
Claims48
A compound of Formula XV:
- or a pharmaceutically acceptable salt thereof;
- wherein:
- R32 is R35;
- R35 is selected from
- R51 is
- R15 is R17;
- R17 is selected from H and —C(O)A;
- A is selected from H, alkyl, cycloalkyl, cycloalkylalkyl, heterocycle, heterocycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, alkyloxy, and alkyloxy;
- and
- x and y are independently selected from an integer between 1 and 30.
7 more elements
The compound of formula
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.