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US 10,117,938 B2Granted
Pharmaceutical formulation
AssigneeSemnur Pharmaceuticals, Inc.
InventorMahendra G. Shah
Life of this patent
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Abstract
Disclosed are aqueous pharmaceutical compositions which provide sustained released delivery of corticosteroid compounds. The pharmaceutical composition comprises a soluble corticosteroid and at least one viscosity enhancing agent. Also provided are methods for using the pharmaceutical compositions in an epidural injection, intra-articular injection, or an intra-lesional injection.
Claims20
A method for treating inflammation and/or pain in an individual in need thereof, comprising:
- injecting an aqueous pharmaceutical composition into the epidural space of the individual, wherein the aqueous pharmaceutical composition comprises:
- a soluble corticosteroid selected from the group consisting of soluble salts and esters of dexamethasone, and
- at least one viscosity enhancing agent,
- wherein the at least one viscosity enhancing agent is sodium hyaluronate or hyaluronic acid, the molecular weight of the at least one viscosity enhancing agent is between 1.0 MDa and 2.5 MDa, and the concentration of the at least one viscosity enhancing agent is between 1.0% w/v and 1.5% w/v;
- and wherein the aqueous pharmaceutical composition is substantially free of insoluble corticosteroids.
2 more elements
Dependencies are inferred from the claim text.