US 10,117,936 B2Granted

Eutectic formulations of cyclobenzaprine hydrochloride and amitriptyline hydrochloride

AssigneeTonix Pharma Holdings Limited

InventorsMarino Nebuloni, Patrizia Colombo

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Abstract

The present invention relates to pharmaceutical compositions and methods of manufacturing the same, comprising a eutectic of Cyclobenzaprine HCl and mannitol or Amitriptyline HCl and mannitol.

Claims34

Dependent claims

A pharmaceutical composition comprising a eutectic of 25%±2% mannitol and 75%±2% Cyclobenzaprine HCl by weight, wherein the mannitol is β-mannitol or δ-mannitol.

Dependencies are inferred from the claim text.

Facts

Application: 14/776,624Filed 14 Mar 2014 · us provisional application
Priority: 15 Mar 2013
Published: US 2016/0030576 A14 Feb 2016
Granted: 6 Nov 2018
Term ends: Not estimatedThe source records don’t support an estimate.

Classification26 codes

A61K 31/135
Amines: having aromatic rings , e.g. ketamine, nortriptyline
A61K 9/145
Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried,…: with…
A61K 9/1623
Organic compounds, e.g. phospholipids, fats: sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
A61K 9/1688
Processes: resulting in pure drug agglomerate optionally containing up to 5% of excipient

Family

Application61/792,757Us provisional application · filed 15 Mar 2013
US 2016/0030576 A1Pre-grant publication · published 4 Feb 2016
US 10,117,936 B2This patent

From the US filing history. Foreign family members aren’t listed.

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