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US 10,117,931 B2Granted
Methods for treatment of age-related macular degeneration
AssigneeKameran Lashkari
InventorKameran Lashkari
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Abstract
The invention provides compositions and methods of predicting a subject's risk of developing age-related macular degeneration (AMD) and methods of treating, delaying, or preventing the development and progression of AMD.
Claims6
A method comprising:
- treating dry AMD (age-related macular degeneration) in a subject by administering to said subject a composition that inhibits an activity of IP-10 (interferon-gamma inducible protein-10) by reducing a level of IP-10 present in the subject after administration of the composition relative to a level of IP-10 present in the subject prior to the administration of the composition, wherein the composition comprises one of a solubilized receptor that binds circulating IP-10, a CXCR3 receptor antagonist or a neutralizing antibody.
A method, comprising:
- treating dry AMD (age-related macular degeneration) in a subject having antibodies at or above an age-related eye disease study (AREDS) stage one by administering to said subject a composition that inhibits an activity of IP-10 (interferon-gamma inducible protein-10) by reducing a level of IP-10 present in the subject after administration of the composition relative to a level of IP-10 present in the subject prior to the administration of the composition wherein the composition comprises one of a solubilized receptor that binds circulating IP-10, a CXCR3 receptor antagonist or a neutralizing antibody.
Dependencies are inferred from the claim text.