Respiratory syncytial virus vaccine
AssigneesVib Vzw, Universiteit Gent
InventorsXavier Saelens, Bert Schepens, Walter Fiers
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Abstract
Described is a vaccine against Respiratory Syncytial Virus (RSV). More specifically, described is a recombinant subunit vaccine comprising the ectodomain of the RSV-encoded Small Hydrophobic (SH) protein. The ectodomain of SH is referred to as SHe. The ectodomain is typically presented as an oligomer, or pentamer. Further described are antibodies, raised against the ectodomain or specific for the ectodomain, and their use for protecting a subject against RSV infection and/or for treatment of an infected subject.
Claims15
A method of evoking protective immunity in a subject against Respiratory Syncytial Virus infection, the method comprising:
- administering to a subject in need thereof an immunogenic composition comprising the ectodomain of the small hydrophobic protein of a Respiratory Syncytial Virus, wherein the ectodomain comprises SEQ ID NO:
- 3, has a length of 23 or 24 amino acids, and has at least 80% sequence identity to SEQ ID NO:
- 1 or 2, and wherein the composition comprises a carrier heterologous to the ectodomain.
Dependencies are inferred from the claim text.