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US 10,117,923 B2Granted
Production of an immunogen using a plant virus
AssigneeVacplanta Limited
InventorsPetr Alexeevich Ivanov, Tatiana Vladimirovna Gasanova, Natalia Vitalievna Petukhova
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Abstract
Provided herein is a recombinant rod-shaped viral particle comprising a fusion protein comprising a coat protein for a rod-shaped plant virus and a epitope from a human and/or human pathogen, where the epitope is disposed on the outer surface of the viral particle. In certain cases, the amino acid sequence of the coat protein is at least 40% identical to the amino acid sequence of the Tobacco Mosaic Virus (TMV) coat protein.
Claims10
A recombinant rigid, rod-shaped chimeric viral particle capable of replication in a plant cell comprising:
- a fusion protein comprising:
- a coat protein that is at least 80% identical to the amino acid sequence of a wild type Tobacco Mosaic Virus (TMV) coat protein, and
- the influenza A virus M2e epitope of SEQ ID NO:
- 1, except that the positions corresponding to cys17 and cys19 of SEQ ID NO:1 in the epitope are each independently substituted by a serine or alanine;
- and
- wherein said epitope is inserted into said coat protein between Ser155 and Gly156 of the TMV coat protein.
3 more elements
Dependencies are inferred from the claim text.