Methods and materials for generating CD8+ T cells having the ability to recognize cancer cells expressing a HER2/neu polypeptide
AssigneeMayo Foundation for Medical Education and Research
InventorsKeith L. Knutson, Andrea M. Henle
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Abstract
This document provides methods and materials for generating CD8− T cells having the ability to recognize cancer cells expressing a HER2/neu polypeptide. For example, methods and materials for using a polypeptide consisting of an SLAFLPESFD amino acid sequence in vivo or in vitro to generate CD8+ T cells having the ability to recognize and lyse cancer cells expressing a HER2/neu polypeptide are provided.
Claims4
A composition comprising an immunogenically effective amount of a polypeptide and an adjuvant selected from the group consisting of a CpG oligonucleotide, monophosphoryl lipid A, and Montanide ISA-51, wherein the sequence of said polypeptide consists of the amino acid sequence set forth in SEQ ID NO:1.
Dependencies are inferred from the claim text.