Antigen-specific T cell receptors and T cell epitopes
AssigneesBioNTech Cell & Gene Therapies GmbH, Translationale Onkologie an der Universitatsmedizin der Johannes Gutenberg-Universitat Mainz gemeinnutzige GmbH
InventorsUgur Sahin, Ozlem Tureci, Petra Simon, Tana Omokoko
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Abstract
The present invention relates to efficient methods for providing antigen-specific lymphoid cells. These lymphoid cells may be used to provide antigen specific T cell receptors having a defined MHC restriction and to identify immunologically relevant T cell epitopes. Furthermore, the present invention relates to antigen-specific T cell receptors and T cell epitopes and their use in immunotherapy.
Claims13
A nucleic acid encoding a T cell receptor selected from the group consisting of:
- (I) a T cell receptor comprising:
- (i) a T cell receptor α-chain comprising all three CDR sequences of T cell receptor α-chain of SEQ ID NO:
- 46, and
- (ii) a T cell receptor β-chain comprising all three of the CDR sequences of T cell receptor β-chain of SEQ ID NO:
- 47;
- and
- (II) a T cell receptor comprising:
- (i) a T cell receptor α-chain comprising the T cell receptor α-chain sequence of SEQ ID NO:
- 46, and
- (ii) a T cell receptor β-chain comprising the T cell receptor β-chain sequence of SEQ ID NO:
- 47.
An antigen-specific lymphoid cell produced by transferring into a lymphoid cell (i) a nucleic acid encoding a T cell receptor α-chain comprising the T cell receptor α-chain sequence of SEQ ID NO:
- 46 and a nucleic acid encoding a T cell receptor β-chain comprising the T cell receptor β-chain sequence of SEQ ID NO:
- 47 or (ii) a nucleic acid encoding a T cell receptor comprising the T cell receptor α-chain sequence of SEQ ID NO:
- 46 and the T cell receptor β-chain sequence of SEQ ID NO:
- 47.
An antigen-specific lymphoid cell produced by transferring into a lymphoid cell (i) a nucleic acid encoding a T cell receptor α-chain comprising all three of the CDR sequences of the T cell receptor α-chain sequence of SEQ ID NO:
- 46 and a nucleic acid encoding a T cell receptor β-chain comprising all three of the CDR sequences of the T cell receptor β-chain sequence of SEQ ID NO:
- 47 or (ii) a nucleic acid encoding a T cell receptor comprising all three of the CDR sequences of the T cell receptor α-chain sequence of SEQ ID NO:
- 46 and all three of the CDR sequences the T cell receptor β-chain sequence of SEQ ID NO:
- 47.
Dependencies are inferred from the claim text.