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US 10,117,897 B2Granted
Constitutive expression of costimulatory ligands on adoptively transferred T lymphocytes
AssigneeMemorial Sloan Kettering Cancer Center
InventorsMichel Sadelain, Matthias Stephan
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Abstract
The present invention provides immunoresponsive cells, including T cells, cytotoxic T cells, regulatory T cells, and Natural Killer (NK) cells, expressing at least one of an antigen-recognizing receptor and a co-stimulatory ligand and methods of use therefore for the treatment of neoplasia and other pathologies where an increase in an antigen-specific immune response is desired.
Claims26
An immunoresponsive cell comprising:
- a) a receptor that binds to an antigen, and
- b) a nucleic acid encoding a recombinant co-stimulatory ligand, wherein the co-stimulatory ligand is a heterologously expressed cytokine, wherein the cytokine is selected from the group consisting of an IL-2, an IL-12 and an IL-21, and wherein the receptor is selected from a group consisting of a chimeric antigen receptor (CAR) and a T cell receptor (TCR).
Dependencies are inferred from the claim text.