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US 10,117,874 B2Granted
Combination of PI3K-inhibitors
AssigneeBayer Pharma Aktiengesellschaft
InventorNingshu Liu
Life of this patent
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Abstract
The present invention relates to combinations of at least two components, component A and component B, component A being an inhibitor of PI3K kinase, and component B being radium 223, particularly a pharmaceutically acceptable salt of radium-223. Another aspect of the present invention relates to the use of such combinations as described herein for the preparation of a medicament for the treatment or prophylaxis of a disease, particularly for the treatment of breast and prostate cancer as well as their bone metatases.
Claims14
A pharmaceutical combination comprising:
- component A, which is 2-amino-N-[7-methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl]pyrimidine-5-carboxamide,
- or a physiologically acceptable salt, solvate, hydrate or stereoisomer thereof;
- and
- component B, which is radium-223 dichloride.
1 more element
Dependencies are inferred from the claim text.