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AssigneeGlaxoSmithKline LLC
InventorsKeith Biggadike, Diane Mary Coe, Xiao Qing Lewell, Charlotte Jane Mitchell, Stephen Allan Smith, Naimisha Trivedi
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Compounds of formula (I): wherein R1 is C1-6alkylamino, C1-6alkoxy, or C3-7cycloalkyloxy; m is an integer having a value of 3 to 6; n is an integer having a value of 0 to 4; and salts thereof are inducers of human interferon. Compounds which induce human interferon may be useful in the treatment of various disorders, for example the treatment of allergic diseases and other inflammatory conditions for example allergic rhinitis and asthma, the treatment of infectious diseases and cancer, and may also be useful as vaccine adjuvants.
A method of treating or preventing a vaccine-treatable or vaccine-preventable disease in a human subject suffering from or susceptible to said disease, the method comprising administering to the human a vaccine composition comprising an antigen or antigen composition, and administering to the human a compound of formula (I):
A method of treating or preventing a vaccine-treatable or vaccine-preventable disease in a human subject suffering from or susceptible to said disease, the method comprising administering to the human a vaccine composition comprising an antigen or antigen composition, and administering to the human 6-amino-2-{[(1S)-1-methylbutyl]oxy}-9-[5-(1-piperidinyl)pentyl]-7,9-dihydro-8H-purin-8-one, or a salt thereof.
Dependencies are inferred from the claim text.