Methods and compositions for sleep disorders and other disorders
AssigneeIntra-Cellular Therapies, Inc.
InventorsSharon Mates, Allen Fienberg, Lawrence P. Wennogle
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Abstract
Use of particular substituted heterocycle fused gamma-carboline compounds as pharmaceuticals and pharmaceutical compositions comprising them for the treatment of one or more disorders involving the 5-HT2A, SERT and/or dopamine D2 pathways are disclosed. In addition, the compounds may be combined with other therapeutic agents for the treatment of one or more sleep disorders, depression, psychosis, dyskinesias, and/or Parkinson's disease or any combinations.
Claims28
A method for the treatment of bipolar depression, comprising administering to a patient in need thereof a Compound of Formula I:
- wherein X is O, —NH or —N(CH3);
- and Y is —O— or —C(O)—, in free or pharmaceutically acceptable salt form.
A method for promoting regular sleep in the treatment:
- of bipolar depression;
- comprising administering to a patient in need thereof:
- an atypical stimulant;
- and
- a Compound of Formula I:
- wherein X is O, —NH or —N(CH3);
- and Y is —O— or —C(O)—, in free or pharmaceutically acceptable salt form.
Dependencies are inferred from the claim text.