Promoting axon regeneration in the adult CNS through control of protein translation
AssigneeChildren's Medical Center Corporation
InventorsZhigang He, Kevin Park, Kai Liu, Yang Hu
Life of this patent
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Abstract
Survival of, or axon regeneration in a lesioned mature central nervous system (CNS) neuron is promoted by (a) contacting the neuron with a therapeutically effective amount of an exogenous activator of protein translation; and (b) detecting the resultant promotion of the survival of, or axon regeneration in the neuron.
Claims10
A method for promoting survival of, and axon regeneration in a lesioned mature human neuron in vivo, wherein the lesion results from a traumatic spinal cord injury arising from physical force, comprising contacting the lesioned neuron with a therapeutically effective amount of a PTEN specific inhibitor to thereby promote survival of, and axon regeneration in the neuron.
A method for promoting axon regeneration in a lesioned mature human central nervous system (CNS) neuron in vivo, wherein the lesion results from a traumatic spinal cord injury arising from physical force, comprising contacting the neuron with a therapeutically effective amount of a PTEN specific inhibitor to thereby promote axon regeneration in the neuron.
A method for promoting axon regeneration in a lesioned mature human neuron in vivo, wherein the lesion results from acute spinal cord injury arising from physical force, comprising contacting the lesioned neuron with a therapeutically effective amount of a PTEN specific inhibitor to thereby promote axon regeneration in the neuron.
Dependencies are inferred from the claim text.